Vado di crossposting, non me ne vogliate
Riporto questa testimonianza, trovata in rete:
"Questa è un’altra paziente curata di recente da Tullio Simoncini da un tumore alla vescica. Anzi, bisogna dire che questa paziente si è curata da sola, perchè Lorna, che vive in Australia, Simoncini non l’ha mai nemmeno incontrato.
Questa è la sintesi dell’intervista, la cui versione completa sarà pubblicata più avanti. Nella versione completa Lorna spiega come ha imparato da sola a posizionare il catetere per i lavaggi con il bicarbonato, e racconta le diverse reazioni dei medici alla sua scelta coraggiosa e apparentemente positiva.
Su Simoncini abbiamo già detto tutto e il contrario di tutto, ...
... per cui ci limitiamo a pubblicare i link agli articoli precedenti, per gli utenti che ancora non conoscessero la vicenda.
Massimo Mazzucco
"
Metodo Simoncini e tumori della pelleLa “grande eresia” di Tullio SimonciniTullio Simoncini: Renaissance ManTratto da:
linkStudi relativi al potere antiacido del bicarbonato di sodio nei tumori:
Anne McLean, “Malignant gliomas display altered pH regu1ation byè NHE1 compared with non transformed astrocytes (Am J Physiol Cell Physiol 278: C676-C688, 2000).
Marion Stubbs, “Causes and consequences of tumour acidity and implications for treatment”, Molecular Medicine: Today, January 2000 (vol.6).
Robert J. Gillies, “Causes and consequences of hypoxia and acidity in turners - Novartis Foundatíon symposium”, Molecular Medicine Vol.7 N° 2 February 2001; “Causes and consequences of hypoxia and acìdity in tumour microenvironments”.
J.R. Griffiths, “Causes and consequences of hypoxia and acìdity in tumour microenvironments”, Glia 1994 Nov:12(3):196-210.
Tannock, I.F., “Acid pH in tumors and its potential for therapeutic exploitation”, Cancer Res 1989 Aug 15;49(16):4373-84.
Raghunand, N., “Enhancement of chemotherapy by manipulation of tumour pH”, Br J Cancer 1999 Jun;80(7):1005-11.
Davydova, I.G., “Dynamics of bioelectric activity of the brain and erythrocyte ultrastructure after intravenous infusion of sodium bicarbonate to oncologic patients.” Biull Eksp Biol Med 1992 Apr;113(4):352-5.
Davydova, I.G., “Characteristics of the effects of artificial alkalosis on electrical activity of the brain and ultrastructure of blood cells in oncologic patients”, Vestn Ross Akad Med Nauk 1995;(4):24-5.
Star, R.A., “Regulatory volume decrease in the presence of HCO3- by single osteosarcoma cells UMR-106-01”, J Biol Chem 1992 Sep 5;267(25):17665-9.
LeBoeuf, R.A., “Intracellular acidification is associated with enhanced morphological transformation in Syrian hamster embryo cells”, Cancer Res 1992 Jan 1;52(1):144-8.
Raghunand, N., “Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone.” Neoplasia. 2001 May-Jun;3(3):227-35.
Raghunand, N., “pH and chemotherapy pH and chemotherapy” Novartis Found Symp. 200 1;240:199-21 l; discussion 265 -8.
Raghunand, N., “Enhancement of chemotherapy by manipulation of tumour pH.” Br J Cancer. 1999 Jun;80(7):1005-1 I.
Raghunand, N., “Tumor acidity, ion trapping and chemotherapeutics. IL pll-dependent partition coefficients predict importance of ion trapping on pharmaeokinetics of weakly basic chemotherapeutie agents.” Bíochem Pharmacol. 2003 Oct 1;66(7):1219-29.”
Mahoney, B.P., “Tumor acidity, ion trapping and chemotherapeutics. I. Acid plì affects the distribution of ehemotherapeutic agents in vitro.” Biochem Phannacol. 2003 Oct 1;66(7):1207-18.
Schornack, P.A., “Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors.” Neoplasia. 2003 Mar-Apr;5(2):135-45.
Giffles, R.J., “MRI of the tumor microenvironment.” J Magn Reson Imaging 2002 Dec; 16(6):75 l.
Torigoe, T., “Vacuolar H(+)-ATPase: funetional mechanisms and potential as a target for cancer chemotherapy.” Anticancer Drugs. 2002 Mar; 13 (3):23 7-43.
Griffiths, J.R., “Why are cancers acidic? A carrier-mediated diffusion model for H+ transport in the interstitial fluid.” Novartis Found Symp. 200 1;240:46-62; discussion 62-7, 152-3.
Webb, S.D., “Modelling tumour acidity and invasion.” Novartis Found Symp. 2001;240:169-8 l; discussion 181-5.
Gillies, R.J., “The tumour microenvironment: causes and consequences of hypoxia and acidity. Introduction.” Novartis Found Symp. 200 1;240:1-6.
Gillies, R.J., “Causes and consequences of hypoxia and acidity in tumors” Novartis Foundation symposium. Trends Mol Med. 2001 Feb;7(2):47-9.
Griffiths, JR. “Causes and consequences of hypoxia and acidity in tumour microenvironments. Bioessays. 2001 Mar;23(3):295-6.
Gillies, R.J., “Causes and effects of heterogeneous perfusion in tumors.” Neoplasia. 1999 Aug; 1 (3):197-207.
Stubbs, M., “Causes and consequences of tumour acidity and implications for treatment.” Mol Med Today. 2000 Jan;6(1):15-9
Stubbs, M., “Causes and consequences of acidic ph in tumors: a magnetic resonance study.” Adv. Enzyme Regul. 1999;39;13-30.
Webb, S.D., “Mathematical modelling of tumour acidity: regulation of intracellular pH.” J Theor Biol. 1999 Jan 21; 196(2);237-50.
Yamagata, M., “The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase.” Br J Cancer. 1998 Jun;77(11):1726~3 I.
Martin, G.R., “Non invasive measurement of interstitial pH profiles in normal and neoplastie tissue using fluorescence ratio imaging microscopy.” Cancer Res. 1994 Nov 1;54(21):5670-4.
Boyer, M.J., “Regulation of intracellular pH in subpopulations of cefis derived from spheroids and solid tumours.” Br J Cancer. 1993 Nov;68(5):890-7.
Newell, K., “Studies with gIyeolysis-dericient celIs suggest that production of lactic acid is not the only cause of tumor acidity.”
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